Products containing histamine in the table. Treatment of histaminosis

Histamine in foods

Many people suffer from histamine intolerance. This amine is capable of inducing an immune response that manifests itself as allergy symptoms. Histamine is released by vasodilating properties and can cause anaphylactic shock. In this case, only an injection of adrenaline can help. That is why you need to know foods containing histamines, and if they are intolerant, you should adjust the diet.

About 1% of the world's inhabitants have histamine intolerance. They are contraindicated in foods high in histamine. Within a very short time after their use, a person feels headache, diarrhea, urticaria and itching occur. Histamine intolerance is most common in middle-aged women.

The use of histamine products leads to the fact that this element accumulates in the body, which causes sad consequences. Some foods do not contain histamine, but help the body produce it. People with histamine intolerance must follow a special diet.

Most often, foods that contain histamine have a long shelf life. They can include all alcoholic drinks. A lot of histamine is found in red wine and sake. Cheeses and smoked meats, seafood and fish are high in histamine. It is worth giving up yeast, soy products, coffee, cocoa and any marinades. Fruits such as kiwi, bananas, pears, pineapples and strawberries also contain histamine.

It is worth noting that many foods contain histamine. But this does not mean that you need to drastically limit your diet. Chastnosti.com magazine presents a list of foods that can be consumed with histamine intolerance.

What can you eat with histamine intolerance

Most often, histamine intolerance is observed as a result of its increase in the body. As a result, the body cannot cope with the load that is placed on it. Many people who consume foods high in histamine cannot figure out why they experience certain symptoms. A person can visit specialists for a long time and look for the cause of frequent headaches, diarrhea or a runny nose.

The causes of histamine intolerance are blocking the production of certain enzymes, ultraviolet radiation and bacterial diseases. Some diseases of the gastrointestinal tract can cause histamine intolerance. Some medications, such as non-steroidal anti-inflammatory drugs, can cause histamine intolerance. If the disease is caused by taking medications, it can be defeated, a replacement can be found.

In order to eliminate histamine intolerance, you need to find the cause of this disease. Do not self-medicate and take drugs that reduce the level of histamine. Be sure to visit a specialist who will give you the necessary recommendations. Self-medication can only aggravate the disease and lead to serious consequences.

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Histamine in foods

Maybe you did not know, but a very large number of people suffer from the fact that the body does not perceive histamine. Since the presence of such a remedy can create an unforeseen immune reaction, in the form of any allergy. But, first of all, it is histamine that is displayed by dilating blood vessels, and this can cause a real anaphylactic shock. And here you can provide help only if you give an injection of adrenaline. And in this case, we call on people to do what is necessary in without fail have information about what foods are high in histamine. And if you abuse such food, then you need to immediately change the diet.

Specific response to histamine

Somewhere within one percent, maybe a little more, the population of our planet is endowed with the property that they cannot tolerate histamine. That is, in fact, they should not eat foods containing histamines at all, especially if the percentage of this substance is very high. What is the risk?

1. The minimum time after eating food with the presence of this remedy and headaches begin to occur.
2. Urticaria or some itching may appear
3. Another discomfort is diarrhea.

According to statistics, it is the middle-aged female who most often experiences rejection of this element. Not quite rosy consequences are visible after the frequent use of foods with the presence of histamine. But it is also worth paying attention to the fact that products defined in their composition do not have this substance, but if they are taken, then as a result, natural histamine synthesis occurs in the body. And people who are prone to allergies to such a substance should always stick to a diet.

Often, such goods and products are stored for a long time, for example, the same alcoholic beverages. Sake or red wine is the alcohol with the highest histamine content. What else should allergy sufferers avoid?

1. Smoked meats different kind(meat or sausages)
2. Cheese, also smoked
3. Almost all seafood
4. Fish with very high levels of histamine
5. Yeast is also banned
6. No more soy products or various marinades
7. No coffee or cocoa either.

You also need to be careful with fruits, because kiwi, pear, pineapple, strawberries and bananas also have a certain amount of histamine.

If you weigh everything, you can see that this supplement contains a very large number of products. But you should not be scared ahead of time, because this absolutely does not mean that your diet should be simplified to a minimum. Just need to know about the list of "foods containing histamine », but those that can be eaten with incompatibility or allergy to the remedy:

• vegetable oil
• Bread or other baked goods such as cookies
• Egg and milk
• Chicken or duck meat
• A plant like corn
• Cottage cheese

The main reason that incompatibility appears in the body is an increased level of histamine in the body, that is, the body simply “fails” because it cannot cope with the load. And even when the production of certain enzymes is blocked or a person is exposed to ultraviolet radiation, or pathogenic bacteria are already present in the body, diseases of the stomach or intestines are also reasons for the incompatibility of the body with a histamine substance.

And in order to solve all the same this problem, it is first of all important to find the source of this disease. And you should not try to cure yourself on your own and recklessly “swallow” drugs that reduce histamine. It is better to find an experienced doctor who will provide you with competent advice and determine the correct method of treatment.

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Histamine in foods

Histamine is a compound that regulates various bodily functions. It can be synthesized in cells or come from outside.

1. The amino acid histidine. Part of some products, it is the basis for the synthesis of histamine in connective tissue. It's called endogenous; is deposited in the form of granules in specialized cells (basophils or mast cells).
2. Food containing histamine. In this case, it is exogenous.
3. Histamine accumulation may also be observed in violation of the intestinal microflora, for example, with dysbacteriosis.

Responses

In cells, histamine is contained in a bound form. Under stress, tissue damage, the action of toxins, foreign agents, etc., it is released and becomes active, which is manifested by a number of reactions:

• spasms of smooth muscles,
• an increase in the amount of hydrochloric acid in the stomach,
• lowering blood pressure,
• expansion of peripheral vessels,
• mucus secretion,
• narrowing of the vessels of the pulmonary circulation,
• swelling of the skin, mucous membranes,
• hyperemia.

Histamine supplied with food and accumulated as a result of improper functioning of the intestine causes the same reactions in the body as the released endogenous one. Manifestations depend on which receptor the interaction occurs with.

There are 3 types of histamine receptors: H1, H2, H3. The first are located in smooth muscles, the membrane of blood vessels, the central nervous system. When binding to H1, the bronchial muscles, intestinal muscles, and blood vessels contract, and the production of prostaglandins increases. Receptors of this type lead to the accumulation of fluid around the vessels, causing edema and hives.

H2 receptors are found in the parietal cells of the stomach. Interacting with them, histamine causes an increase in the activity of the glands of the stomach, the formation of mucus. Simultaneous stimulation of H1 and H2 leads to the expansion of peripheral vessels and the onset of itching. H3 receptors, located in the central nervous system and peripheral parts of the nervous system, suppress the release of serotonin, norepinephrine and other neurotransmitters.

Free histamine can be bound to blood proteins or inactivated by the enzymes methylhistamine and histaminase. This process occurs in the liver, connective tissue, placenta, kidneys. Inactivated, it is stored again in mast cells. A small amount is excreted in the urine.

Foods can directly cause the release of endogenous histamine, leading to the development of an allergic reaction, or they themselves are a source of its increased amount, causing food intolerance. In the latter case, histamine, entering the body, causes manifestations similar to true allergies.

The level of histamine in products is regulated by certain standards. Thus, according to Russian standards, its content in fish, for example, should not exceed 100 mg/kg.

The following products cause the activation of their own histamine:

• strawberry,
• chocolate,
• alcohol,
• pig liver,
• egg white,
• wheat,
• shrimps,
• artificial additives (dyes, preservatives, etc.).

High histamine foods include:

The amount of histamine in foods can increase significantly if they are not properly stored, violated the conditions of transportation, canned and frozen. After eating such food, responses to it can be even in healthy people.

Since histamine is quickly inactivated, not very pronounced single manifestations can go away on their own. However, in the case of numerous and vivid reactions, it is necessary to take antihistamines (according to the instructions for use). Histamine poisoning can lead to suffocation, convulsions, and death.

Application in medicine

Histamine can be used to treat diseases, for research and diagnosis. When assessing the functional state of the stomach, a solution of histamine hydrochloride of a certain concentration is used. The goal is to stimulate the secretion of gastric juice.

As medicinal product histamine is used in the following diseases:

• polyarthritis,
• myeloid leukemia,
• rheumatism,
• allergic reactions,
• radiculitis,
• pain of nervous origin.

Indications for the use of histamine are also migraine, urticaria, bronchial asthma.

Histamine as a medicine is used in the form of an ointment, injections, and is used in electrophoresis. Instructions for the drug Histamine contains a fairly extensive list side effects and contraindications, so its purpose and dosage should be under the supervision of a doctor.

In addition, in pharmacology there are preparations containing a combination of histamine with other active substances. For example, its combination with serum immunoglobulin (hystaglobulin) is indicated for use during the period of remission of allergic diseases. Such a complex increases the ability of the blood to inactivate free histamine.

For the treatment of allergies of various origins, the so-called dosed histamine immunotherapy is used. Its goal is the gradual development of insensitivity to a certain level of histamine in the blood. This approach makes it possible to select an individual amount of the drug and keep responses under control.

When allergies appear, you need to properly review your diet, paying attention to simple, natural products. It will not be superfluous to cleanse the body with herbs. It is necessary to monitor the intestines, which also depends on the food consumed. After all, it may well turn out that a banal refusal from sausages will return health and strength.

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Histamine cycle-2: low-histamine diet, microflora, stress. We continue the conversation about an important substance - histamine, and today we will figure out why the histamine imbalance is so often disturbed. Let me remind you that the main function of histamine is to be on guard, raising the alarm in case of any threat, be it an injury or an infection. Histamine triggers a powerful inflammatory response, setting the stage for immune cells to work. But now the conditions of our life are changing. There are fewer injuries and infections, so there are fewer opportunities for the usual work of histamine. But instead, we experience more stress, which provokes a constant release of histamine and we eat less and less. Poor nutrition has different effects. On the one hand, we consume an excess of foods that contain a lot of histamine, and on the other hand, we eat too little. useful products containing vitamins and minerals necessary to eliminate excess histamine.

Every day, our body is tested for strength by the environment. Well, if it happens outside the city and the only irritant is "oxygen poisoning". But what if we are talking about a multimillion-dollar metropolis with polluted air, a lot of pollution and unhealthy food? We will dwell on the last point in more detail, since very often, having snatched half an hour between meetings, people do not think about what they eat. And in vain, because then some of them blush and not because of the quality of the food. It was histamine that came into action, which is too much and which did not have time to decompose due to the work of diamine oxidase. We have previously talked about histamine intolerance or pseudo-allergy , the reasons for this imbalance and ways to detect it . In this note, we will try to formulate the basis for a responsible approach to nutrition in the presence of DAO deficiency.

Histamine is constantly present in our body and its concentration increases during the digestive processes, since it is directly involved in them. However, there is a significant list of products that contain a fairly large amount of this compound. And some contain oxidase blockers. Here are some examples of products that
RICH IN HISTAMINE:

• Alcoholic beverages obtained by fermentation (wine, champagne, beer);
• Fermentation products: sauerkraut, vinaigrette, soy sauce, kefir, yogurt, sambuca, etc.;
• Products containing vinegar: salted cucumbers, mayonnaise, olives;
• Dried or salted meat: bacon, salami, pepperoni, basturma, jamon;
• Acidic foods: sour cream, milk, acidified bread, etc.;
• Dried fruits: apricots, prunes, figs, raisins;
• Most citrus;
• Aged cheese, including goat;
• Nuts: walnuts, cashews, peanuts;
• Vegetables: avocado, eggplant, spinach, tomatoes;
• Some types of fish and smoked fish: mackerel, tuna, anchovies, sardines.

But besides them, there are also foods that contribute to the release of histamine.
These are HISTAMINE LIBERATORS:

• alcohol,
• bananas,
• chocolate,
• cow's milk,
• nuts,
• shellfish,
• strawberry,
• tomatoes,
• wheat germ,
• many artificial preservatives and colors.

The group of DAO BLOCKERS includes a number of drinks, such as:

• alcoholic,
• energy
• teas (black, mate and green).

Looking at these lists, you might think that life will end soon and you need to switch to bread. However, if a person notices clear signs of histamine intolerance, it is necessary to make adjustments to the diet. And it is wiser to do this under the supervision of a doctor who knows exactly the individual parameters of the patient. Quite often, such intolerances develop against the background of the syndrome of increased intestinal permeability (also known as the "leaky gut" syndrome). On the one hand, it is necessary to attend to the treatment of the cause of this syndrome, and on the other hand, not to delay the transition to a low-histamine or no-histamine diet at all. Most often, high intestinal permeability is the cause of many food intolerances. And even chronic stress when cortisol levels rise can lead to similar consequences.
Three tasks need to be solved:

• heal your intestines, (including as a consequence of chronic stress),
• adjust the daily diet in the direction of minimizing histamine,
• eliminate the possibility of its excess synthesis.

In addition to the last point, you can make a list of products, without fear for the balance of histamine and DAO, which
YOU CAN USE:

• Freshly cooked meat, poultry meat (frozen or fresh);
• Freshly caught fish;
• Eggs;
• Gluten-free grains: rice, quinoa; buckwheat
• Pure peanut butter;
• Fresh fruits: mango, pear, watermelon, apple, kiwi, melon, grapes;
• Fresh vegetables (except tomatoes, spinach, avocado, and eggplant)
• Milk substitutes: coconut milk, rice milk, almond milk;
• Vegetable oils: olive oil, coconut oil;
• leafy herbs;
• Herbal teas.

It is possible to detect histamine intolerance or DAO deficiency in an alternative way, by setting up a fairly long experiment under the supervision of a physician. To do this, you need to remove histamine-rich foods from the diet for 2-3 months. The most important thing here is to find the cause of the imbalance. If the patient is taking medications that cause a pseudo-allergic reaction, then it is necessary to talk with the doctor about stopping it, if possible. Leaky gut syndrome is often caused by an overgrowth of bacteria in the small intestine, gluten intolerance, and chronic stress. If this is the reason, then first you need to deal with the intestines, the nervous system and the psycho-emotional state, after which the balance of DAO will be restored and it will be possible to return to histamine-rich foods. In other words, histamine intolerance is not a sentence, it will not last a lifetime if it is found in a patient. Diet modification will in a good way return the balance of histamine and oxidase to optimal values.
If it turns out that the patient does not produce enough of his own diamine oxidase, then the doctor may prescribe the intake of its drugs. Most patients can avoid the need for it by making only minor adjustments to their lifestyle and diet. After all, it often happens that the solution to the problem lies on the surface.

A number of articles will appear on the site, where they will be given useful to people intolerant

• lactose,
• gluten,
• fructose,
• histamine;

• for cholesterol levels
• blood sugar level,
• at .

Intolerance food products is primarily a difficulty in digesting certain foods. Most often these are products, as:

• milk products,
• cereals,
• citrus
• and foods that cause gas to build up in the intestines.

Why is it important? Often, intolerance to certain foods is one of the main causes of metabolic disorders in the body, which leads to the occurrence of chronic diseases.
Food intolerance can masquerade as various diseases. Deposits in fat cells of poorly digestible components and fluid retention in tissues due to impaired renal function leads to a steady increase in body weight.

Rules for eating…

What is histamine?
Histamine belongs to the group of so-called biogenic amines, which are found naturally in food. Biogenic amines arise from amino acids, the building blocks for proteins. Just as a word is made up of different letters, a protein (protein) is made up of different amino acids. These amino acids can become biogenic amines during storage or heating food .
With histamine intolerance, not only histamine itself, but also other biogenic amines cause discomfort. Strictly speaking, this is the incompatibility of biogenic amines.

Histamine plays an important role in the human body.

For example, he acts

• like a hormone
• and stimulates the work of nerve cells;
• it participates in the formation of gastric juice
• and affects the rhythm of sleep.

If there allergic reaction , then the cells located in the skin and digestive tract in the mucous membrane release some of the contents, including histamine. This release of histamine eventually leads to symptoms

• Stomach pain, bloating, nausea, belching
• Abdominal pain, intestinal cramps, bloating, diarrhea
• Headache, migraine
• Dizziness, drowsiness
• Chronically low blood pressure or severe changes in blood pressure
• Frequent sneezing and runny nose
• Skin irritation, itching, urticaria, eczema
• Eye redness, itching
• Arrhythmia
• Labored breathing
• menstrual problems

For example, with histamine intolerance tomato sauce causes bloating with belching five minutes after eating, causes flatulence after four hours, and then causes headaches and diarrhea the next day.

It is estimated that one to five percent of the population suffers from histamine intolerance, and at least 80 percent of them are women.

The most common intolerance products

• Alcohol, especially red wine and sparkling wine
• Tomatoes, especially in concentrated form (tomato paste, ketchup, sauces)
• Sauerkraut, spinach
• Canned and smoked fish (e.g. tuna, herring, salmon, mackerel, sardines)
• Strawberries, kiwi, bananas, oranges, pineapple
• Hazelnuts, peanuts, walnuts
• Chocolate

• Sausage (such as salami), cured meats (such as raw ham)
• Hard cheeses (aged cheese, e.g. Emmentaler, Gouda)

Stage 1

At the first stage, you should refrain from all of us foods and drinks containing a significant amount of biogenic amines.
Target three-week phase - significantly reduce symptoms or even stop them.

If you suffer from abdominal discomfort, it is recommended that you refrain from indigestible foods such as wholemeal bread, cabbage, onions, and legumes at the start of your diet change.

If soft stools are observed, preference should be given to white bread or buns, in which there is almost no fiber.

News symptom log so that any dietary errors can be easily identified and corrected.

Also

• Eat slowly and chew thoroughly
• Drink enough (1.5-2 liters per day)
• Eat 4-5 meals throughout the day
• Eat moderate portion sizes

Stage 1. Products

• Still mineral water, grain coffee, herbal tea, fruit tea, max. 2 cups a day: black and green tea
• Apple, pear, cherry and peach juice, lemonade, sugar-free lemonade, malt beer, carrot juice; herbal drinks: soy drink, rice drink, oatmeal drink
• Chicory, fennel, cucumber, pumpkin, carrots, yellow and red peppers, parsnips, mushrooms, radishes, beets, celery, asparagus, celery, swede, zucchini, sugar peas
• Lettuce, a small portion of raw vegetable salad
• Prepared meals without glutamate and yeast extract
• soy drink, tofu

Only if the symptoms are not observed for several days, you can go to the second phase - the testing stage.

Stage 2

In the second phase food is tested for its compatibility. Many patients can only tolerate small amounts of food.
Moreover, women, please note that the tolerance of "suspicious" products a few days before menstruation can be much worse than in other periods.

However, you should not test more than one product per day. Wait about 24 hours after each test to assess your tolerance.
Many sufferers need to enter the result in the so-called complaints barometer (lead symptom log). Here, mark the compatibility of the tested product. Tests taken by women on the days before their period should be logically marked or written in other ink.

The trial phase usually lasts four to six weeks.

If you suffer from abdominal discomfort, then onions, beans, lentils, leeks and cabbage should be returned to the diet very sparingly.

Food choices for histamine intolerance

Stage 2. Products

• Carbonated mineral water
• Coffee (not freshly brewed)
• Beer, white wine, vodka, fruit liqueur, herbal liqueur, whiskey, sherry, cream liqueur
• cauliflower, broccoli, Chinese cabbage, cabbage, garlic, kohlrabi, leek, corn, green pepper, Brussels sprouts, red cabbage, kale, savoy cabbage, onion
• A fresh vegetable salad
• 1-2 fresh tomatoes, olives
• Prepared meals with glutamate or yeast extract
• Fresh green peas and canned, white, red and other beans
• Lentils, fresh soybeans
• Soy sauce

Stage 3

This stage is long-term .
Just have to refuse from foods that lead to noticeable discomfort. Foods that are well tolerated by the body are allowed.

If the condition worsens again after several weeks of trying, this is usually due to the fact that too many different foods with histamine are consumed - albeit in small quantities. In this case, you will have to consume foods and drinks from the first stage. Until you get better.

If a person additionally suffers from other intolerances, associated with food allergies , then complete balanced diet in the long run it is often very difficult to achieve.

In this case, your problems you must solve with an experienced nutritionist to provide your body with all the nutrients for a long period.

• Orange, pineapple and multivitamin juice
• Red wine, sparkling wine
• Cocoa
• Vegetable juice with tomatoes, sauerkraut juice
• eggplant, spinach, sauerkraut, tomato sauce, ketchup, pasta

Hand in hand -

With histamine intolerance, medication intolerance is also observed.

For safety consult a doctor before taking medication!

Under no circumstances should medications be "prescribed" on their own!

Besides, attending dentist should be informed about histamine intolerance, as local anesthetics are often poorly tolerated.

Diagnosis - how to recognize incompatibility?

Only after that when three weeks old stage 1- low in histamine

• remains asymptomatic;

• in the next stage 2- introduction of histamine-rich food - symptoms worsen,

it's probably histamine intolerance.

1. Bring in all consumed products; their number; the time of their use.
2. Enter all drinks and the time of their use. Also water!
3. Keep notes immediately after eating, at the end of the day it is easy to forget this or that.
4. Record the intake of vitamin preparations, dietary supplements, etc.
5. Write down all painful symptoms and the time of their onset (!).
6. Emptying the bowels.

Tables (example)

If necessary, show the journal to a doctor or nutritionist.

Make potato muffins

140 kcal

Ingredients 12 servings

• 200 g starchy potatoes
• 150 g turkey schnitzel
• 1 tablespoon oil
• 1 sprig rosemary
• 200 g flour
• 2 teaspoons baking powder
• 60 g butter
• 1 egg
• pepper
• 150 ml milk

Also: 12 paper molds; 1 metal with 12 notches, 7.5 cm each

How to cook

1. Peel potatoes, boil in boiling salted water for about 15 minutes, drain and then cool slightly.
2. Rinse the turkey meat and dry it, cut into a cube of about 1 cm. Heat the oil in a pan and fry the meat in it for about 5 minutes. Remove from pan.
3. Wash rosemary, dry and finely chop.
4. Mix flour and baking powder.
5. Melt butter and add.
6. Crush the potatoes roughly, add to the flour with the egg, rosemary and meat and knead the dough. Season.
7. Slowly mix with a wooden spoon with milk to get a sticky dough.
8. Place paper cups in the recesses of the baking dish.
9. Put the dough into molds.
10. Bake the cupcakes in the oven at 200°C (do not preheat) for about 20 minutes.

Pseudoallergy with histamine intolerance, like true allergy, occurs with an increase in the level of histamine in the blood plasma, but without an immunological antigen-antibody reaction.

Principle of treatment

To successfully combat pseudo-allergies, you must:

• Prevent the intake of histamine from the outside. Exogenous histamine comes to us as part of food. Therefore, you should abandon these products or at least limit their intake as much as possible.
• Prevent the formation of endogenous (internal) histamine from mast cells. Avoid factors that promote degranulation of mast cells with the release of histamine. Among these factors: overheating and hypothermia, insolation, physical exercise, emotional stress, infectious diseases. Strengthening mast cell membranes also prevents their degranulation.
• Accelerate the breakdown of histamine. For this, it is necessary to stimulate production of DAO (diaminoxidase). It is an enzyme synthesized by the cells of the small intestine breaks down histamine. Accordingly, in some chronic diseases of the gastrointestinal tract (GIT) DAO synthesis will be impaired, which can lead to histamine intolerance.
• Elimination of manifestations histaminosis - shortness of breath, edema, skin itching, digestive disorders.
• Comprehensive treatment of histaminosis involves the use of various drug groups. In addition, severe food restrictions are necessary. Diet for histaminosis is no less important than drug therapy.

Preparations

• Membrane stabilizers. This is an extensive group of drugs that stabilize mast cell membranes and prevent their degranulation. Membrane stabilizers include Ketotifen and numerous analogues of cromoglycic acid. These drugs have been used for the past decades to treat allergic and pseudo-allergic conditions.
• Histamine antiliberators. Not to be confused with antihistamines, which only block histamine receptors. Anti-liberators prevent the release of histamine from mast cells, and to a certain extent are also membrane stabilizers. The group of anti-liberators includes sympathomimetics - substances that stimulate the sympathetic nervous system through adrenergic receptors. The most famous of them - Adrenalin, which can be used for emergency elimination of such manifestations of pseudo-allergies as Quincke's edema and bronchospasm. Beta-2-adrenergic stimulants contribute to the expansion of the bronchi. True, these drugs can negatively affect the work of the heart - increase the strength and frequency of heart contractions, cause rhythm disturbances. Therefore, in clinical practice, drugs are used that selectively affect the smooth muscles of the bronchi - Fenoterol, Salbutamol.
• Glucocorticoids . Synthetic analogues of the adrenal cortex (Prednisolone, Dexamethasone) also strengthen the membranes, stabilize blood circulation and prevent the release of free histamine. These drugs can be taken orally or applied externally in the form of ointments when an itchy skin rash appears. Glucocorticoids should not be used for a long time due to the serious side effects of these drugs.
• Vitamins and minerals . Pyridoxine hydrochloride (vit. B6), ascorbic acid (vit. C) are involved in the synthesis of DAO. In addition, ascorbic acid is an excellent membrane stabilizer. Vit. E is a natural antioxidant and membrane stabilizer. Metals such as copper, zinc, and magnesium are also involved in the synthesis of DAO. Calcium perfectly strengthens membranes. Vitamins and minerals in various combinations are available in the form of numerous pharmaceuticals and dietary supplements.
• Histaglobulin. The preparation includes histamine hydrochloride and human blood gamma globulin. Histaglobulin promotes the release of specific antibodies that neutralize free histamine.

• Probiotics and Prebiotics . Probiotics are products that include cultures of the intestinal microflora, including lactobacilli and bifidumbacteria. Prebiotics are substances that stimulate the growth of this microflora. These include pantothenic acid (vit. B5), inulin, and many other complex carbohydrate compounds. Probiotics and prebiotics are represented by pharmaceuticals and dietary supplements. Restoration of the intestinal microflora not only improves digestion, but also stimulates the formation of DAO by enterocytes.
• Enterosorbents . Sorption and removal of toxins from the intestines in chronic bowel diseases (leaky gut syndrome) also promotes the synthesis of DAO.
• Digestive enzymes . Creon and its analogues improve intestinal digestion, and thereby prevent the accumulation of toxins in the intestine and the destruction of DAO.
• L-gluten - this amino acid promotes the regeneration of intestinal cells during their inflammation, and thus stimulates the synthesis of DAO. However, L-gluten is categorically contraindicated in celiac disease - a genetic or acquired intolerance to a group of plant proteins, gluten.

As can be seen, the same agent can affect several factors of histamine intolerance.

Diet

The elimination diet involves the complete exclusion of foods that contribute to histamine intolerance. In order to prevent the entry of histamine into the body, it is necessary to abandon foods rich in this compound. These products include:



• Fermented cheeses;
• Sauerkraut;
• Pork liver, beef brains;
• Sausages, sausages, ham;
• Fish, fish caviar, crustaceans, seafood;
• Tomatoes, spinach;
• Legumes (beans, peanuts);
• Cocoa, chocolate;
• Strawberry.

In addition to histamine, these foods may contain the amino acid histidine, which is a precursor to histamine.




Here are the products that increase the release of histamine from mast cells :



• Strawberries, wild strawberries, citrus fruits;
• Dried fruits;
• Egg white;
• Fish, caviar, seafood;
• Tomatoes, fresh cabbage, eggplant, radish;
• Spices - pepper, cinnamon, cloves, nutmeg;
• Coffee, chocolate, tea, cocoa.



It is easy to see that some foods rich in histamine can also promote its release from mast cells. Food that is too hot or cold can also release histamine. The same applies to semi-finished products and other products that have been frozen and then thawed.




All flavor enhancers, stabilizers, dyes, preservatives also contribute to the release of histamine. Therefore, it is undesirable to take smoked meats, fish, meat, canned vegetables and other products intended for long-term storage.




For the same reason, you should not use soft drinks, ice cream, confectionery, mayonnaise.




Alcohol not only enhances the release of histamine, but also inhibits the synthesis of DAO (this is mainly due to the breakdown intermediate, acetaldehyde). Therefore, alcohol with pseudo-allergy is prohibited. This applies not only to strong drinks (vodka, cognac), but also to weaker products of alcoholic fermentation (wine, beer).




In cases where pseudo-allergy has developed against the background of celiac disease, it is necessary to adhere to gluten free diet.




Gluten or gluten contains cereals - wheat, barley, rye, oats, as well as bakery and confectionery products, pasta, cereals prepared from them.

What then is possible? Elimination Diet for histamine infections includes:



• Rice, buckwheat;
• cucumbers;
• Fresh fruits - pears, apples, grapes, kiwi, watermelon;
• Herbal teas.



It is allowed to include in the diet a small amount of fresh meat grown at home (beef, poultry), and freshly caught fish. It is desirable that meat or fish be boiled or cooked in olive oil. The elimination diet is quite rigid, and usually long-term. Its duration depends on the causes of histamine intolerance, the severity of clinical manifestations, and the success of drug treatment.

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