Unidox Solutab indications for use. Unidox Solutab - instructions for use, indications, composition, side effects, analogues and price

Content

Among broad-spectrum antibiotics, this drug occupies a special place. Unidox Solutab tablets are highly effective in combating a huge number of bacteria, so they are often prescribed for the treatment of acne, urethritis and diseases associated with visual impairment. The tool acts powerfully, but at the same time delicately, without causing damage to the human body. For this reason, it is recommended by many leading experts. More detailed information about the drug is provided in the continuation of the article.

Unidox Solutab - instructions for use

The effectiveness of this remedy will be readily confirmed by millions of people who have taken it. Nevertheless, before you start using Unidox Solutab for the treatment of a particular disease, you need to consult a doctor and study the instructions in detail. Like any other medicine, this drug can harm the body if taken incorrectly. Official instructions and recommendations from a specialist will help you protect yourself from mistakes.

Compound

The main active ingredient of the drug is doxycycline - an antibiotic belonging to the group of tetracyclines. It is obtained by the most complex chemical synthesis. In the laboratory, pharmacists modify tetracycline, which is formed in nature by a special kind of fungus, and get doxycycline, which can cure a person from many ailments. Additional components help him with this. The full composition of one tablet of the drug is as follows:

• doxycycline - 100 mg;
• lactose monohydrate - 250 mg;
• microcrystalline cellulose - 45 mg;
• low-substituted hyprolose - 18.75 mg;
• saccharin - 10 mg;
• hypromellose - 3.75 mg;
• magnesium stearate - 2 mg;
• colloidal silicon dioxide - 0.625 mg.

Release form

Dispersible biconvex tablets. The color varies from light yellow to gray-yellow. On one side of the tablet there is a risk, on the other - the engraving "173", meaning the drug code. Supplied in cardboard boxes. One package contains 10 tablets. Store the drug at a temperature of 15 to 25 ° C. The shelf life of the drug is 5 years.

Indications for use

The drug can be prescribed if the patient has infectious and inflammatory disorders caused by microorganisms sensitive to doxycycline. The antibiotic has demonstrated its effectiveness in combating diseases such as:

• infections of ENT organs: tonsillitis, otitis media, sinusitis, etc.;
• respiratory tract infections: acute bronchitis, tracheitis, pharyngitis, lobar pneumonia, bronchopneumonia, lung empyema, lung abscess, etc.;
• sexually transmitted infections: urogenital chlamydia, uncomplicated gonorrhea, venereal lymphogranuloma, inguinal granuloma, syphilis (in patients with individual intolerance to penicillins);
• infections genitourinary system: pyelonephritis, cystitis, urethrocystitis, urethritis, acute orchiepididymitis, urogenital mycoplasmosis, endometritis, salpingoophoritis and endocervicitis;
• infections of the biliary tract and gastrointestinal tract: yersiniosis, cholangitis, diarrhea, cholera, cholecystitis, gastroenterocolitis, amoebic and bacillary dysentery;
• infectious eye diseases;
• wound infections of the skin transmitted by animal bites;
• other diseases: sepsis, osteomyelitis, peritonitis, subacute septic endocarditis, malaria, leptospirosis, brucellosis, tularemia, actinomycosis, adnexitis, prostatitis, whooping cough, inflammation of the appendages, severe acne.

Contraindications

The list of cases in which the use of tetracyclines is prohibited:

• hypersensitivity to the active substance;
• pregnancy;
• lactation period (breastfeeding) - the antibiotic negatively affects breast milk;
• childhood(up to 8 years);
• porphyria;
• severe kidney and / or liver dysfunction.

Method of application and dosage

To increase the absorption of active ingredients, it is necessary to dissolve the tablets in a small amount of water (20-25 ml) and drink the resulting liquid during meals. Average duration The course of treatment is 5-10 days. It is not recommended to take the drug before bedtime. In addition, the combination of tetracyclines with alcohol is strictly prohibited.

For adults and children over 8 years of age, weighing more than 50 kg, a dose of 200 mg is prescribed on the first day of treatment. Taken 1 or 2 times. For the following days, 100 mg of the drug per day is prescribed. Patients weighing less than 50 kg daily allowance calculated in the ratio of 2 mg/kg. During the first day of the treatment course, you must take a double dose.

special instructions

Prescribing the antibiotic Unidox Solutab, doctors in without fail warn of possible cross-hypersensitivity and resistance with other tetracycline-based drugs. In addition, the active components of the drug can significantly increase the prothrombin time. With long-term treatment, the drug is not safe for all patients. There are a number of cases in which careful monitoring of physicians is required:

• the patient has coagulopathy;
• kidney failure;
• esophageal ulcer and esophagitis;
• dysbacteriosis.

During pregnancy

Doxycycline is able to penetrate the hemato-placental barrier and have an adverse effect on the fetus. For this reason, it is prohibited for pregnant women. An exception to the rule is the presence of rare bacterial infections requiring treatment with doxycycline (inhalation exposure to Anthracis Bacillus, Rocky Mountain spotted fever, etc.).

In childhood

For persons under 8 years of age, the use of tetracycline drugs is contraindicated. This limitation was established due to the fact that during the period of tooth formation, decay particles of the active substance accumulate in the dental tissue and gradually lead to an irreversible discoloration of the enamel. However, the doctor may prescribe a doxycycline-based medicine to the child if a medical condition requires it. When it comes to saving a patient's life, the color of the teeth is not that important.

With violations of the functions of the kidneys and liver

In such cases, doctors prescribe doxycycline drugs with extreme caution. It is very dangerous to treat severe liver and kidney diseases with tetracycline-based drugs, but in cases where other drugs cannot be effectively used, there is no choice. If absolutely necessary, the doctor may prescribe a small dose of the drug. In order to avoid negative consequences, additional monitoring of the patient's condition will be required - monitoring changes in symptoms and regular blood tests to monitor the concentration of doxycycline.

Interaction with other drugs

The course of therapy, which includes taking Unidox Solutab, should be made taking into account the characteristics of other drugs. In this matter, it is important to pay attention to the following nuances:

1. Magnesium-based laxatives, sodium bicarbonate, iron preparations, antacids containing magnesium, aluminum and calcium reduce the absorption of doxycycline. For this reason, their application should be separated by a 3-hour interval.
2. When tetracyclines are combined with bactericidal antibiotics based on cephalosporins and penicillins, the effectiveness of the latter is reduced. This fact must be taken into account in the fight against diseases such as tonsillopharyngitis and meningitis.
3. Drugs that accelerate metabolism (barbiturates, ethanol, phenytoin, etc.) reduce the concentration of doxycycline in the blood, which leads to a weakening of the therapeutic effect.
4. With the simultaneous use of hormonal estrogen-containing contraceptives and doxycycline antibiotics, the reliability of protection against fertilization decreases. It is important for sexually active patients to keep this in mind.
5. The combination of retinol and doxycycline leads to an increase in pressure in the vessels of the brain.

Unidox Solutab - side effects

The issue of adverse reactions of the drug to the human body must be considered from several sides at once:

1. Digestive system. The following symptoms and diseases may appear: anorexia, vomiting, nausea, disruption of the intestinal microflora, dysphagia, diarrhea, enterocolitis, esophagitis, cholestasis, esophageal ulcer, liver damage (in patients with hepatic or renal insufficiency taking the drug for a long time).
2. Dermatological reactions. Treatment with tetracyclines may contribute to the development of photosensitivity, exfoliative dermatitis, erythematous and maculopapular rash.
3. Allergic reactions. Often, tetracyclines cause exacerbation of systemic lupus erythematosus and the appearance of pericarditis, erythema multiforme, angioedema, urticaria, etc.
4. Endocrine system. In patients taking doxycycline-based drugs for a long time, reversible dark brown staining of the thyroid tissue often occurs.
5. CNS. Possible violations nervous system when using tetracyclines: vestibular abnormalities (unstability, dizziness), double vision, decreased visual clarity.
6. Urinary system. Long-term treatment with tetracyclines can lead to an increase in residual urea nitrogen (the reason for this is the anti-anabolic effect).
7. Musculoskeletal system. The active component of the drug slows down osteogenesis and disrupts the development of teeth in children (it provokes the development of enamel hypoplasia).
8. Other violations. The manifestation of superinfection is candidiasis (stomatitis, vaginitis, glossitis, proctitis).

Overdose

Symptoms:

• vomit;
• jaundice;
• increased levels of transaminases;
• feverish state;
• azotemia.

An overdose of Unidox Solutab requires immediate treatment. To return the body to normal, it will be necessary to gastric lavage, induction of vomiting, drinking plenty of water, taking osmotic laxatives and activated carbon. The use of techniques such as hemodialysis and peritoneal dialysis is not recommended due to their low efficiency.

Analogues

In Russian pharmacies, you can find many drugs based on doxycycline with a similar composition. Subject to the doctor's prescriptions, any analogue of Unidox Solutab will provide a full-fledged therapeutic effect. However, in order to avoid unwanted reactions of the body, it is worth consulting with your doctor about the possibility of using an alternative remedy.

Price Unidox Solutab

Analogues of the drug almost always have the same composition. Differences are found only in the set of auxiliary components. The active substance is always the same - doxycycline. The cost of drugs from different manufacturers may differ more significantly. The table below will help you navigate the prices of tetracycline drugs.

How to take Unidox Solutab from ureaplasma - this question often worries patients. Unidox Solutab is an antibiotic belonging to the tetracycline group. Most often it is used in the treatment different kind infectious diseases. It may well be prescribed for genital ureaplasmosis parvum (ureaplasma parvum).

Antibiotic action

This disease most often affects those who are diagnosed with infertility or those who constantly suffer from inflammatory diseases of the genital organs, since ureaplasmas are specific bacteria that cause inflammation. They infect the urinary and reproductive systems.

According to statistics, almost 70% of men and women on the planet have ureaplasma in their bodies. But most often they suffer from women. Still at risk are people with weak immunity, HIV-infected.

The drug is produced in the Netherlands on the basis of the Astellas concern. The product is available in the form of yellow-white or yellow-gray tablets. One side is marked "173". Each tablet contains 100 mg of the active ingredient. One package contains 10 tablets.

How is Unidox Solutab treated? This antibiotic is quite strong, so the doctor, when prescribing it, must remember the individual characteristics of the patient, the presence or absence of pathogens of other infectious diseases, as well as allergies to antibiotics of the tetracycline group. It is impossible to prescribe and drink the remedy on your own.

If all factors are taken into account, it will be much easier to treat the patient. The dosage of the drug and the duration of treatment is prescribed by the doctor, depending on the nature of the course of the disease. The effect appears soon after the start of therapy.

How to take Unidox Solutab?

The drug can be consumed both in solid form, washed down with water, and dissolved in water. The manufacturer believes that in both forms it will work effectively and is quickly absorbed in the body.

Stages of treatment:

1. With ureaplasmosis, the duration of treatment can be 7 days. This is quite enough for a complete recovery.
2. Treatment is continued only if there are any complications.
3. After 7-8 days of treatment, the patient is prescribed a second one. This is necessary in order to understand whether the antibiotic is effective. If there is no qualitative improvement, then the antibiotic is changed.

Doctors note that there are no pronounced side effects in the treatment of ureaplasmosis with Unidox Salutab. Diarrhea is possible, but when it occurs, doctors should immediately replace the antibiotic.

Only in exceptional cases, when there are several concomitant infections, or when the patient's immune system is extremely weak, Unidox Salutab is ineffective in ureaplasma. In such cases, doctors usually change antibiotics and prescribe a longer course of treatment.

During treatment, it is necessary to take the drug to both partners in the same way.

The drug does not have a serious effect on the functioning of the kidneys, so that patients with renal insufficiency may well be prescribed.

Both partners are assigned high-calorie. The only absolute contraindication for nutrition is the consumption of milk and dairy products, since the drug, reacting with them, forms insoluble compounds - chelates, which reduce the effects of antibiotic exposure.

It should be noted that the drug can be taken both on a full and on an empty stomach. It does not decrease its efficiency.

special instructions

Antibiotic treatment and alcohol consumption are incompatible. After the end of the course of treatment, it is necessary to refrain from strong drinks for at least another week. This time is necessary for the substance to be completely eliminated from the body.

Doctors do not recommend taking other tablets with a high iron content and antibiotics containing doxycycline (the main active ingredient of the drug, which prevents the development and spread of pathogenic bacteria) during the period of treatment with these drugs.

What is added extra?

Another mandatory item is complex treatment. During the period of taking the drug Unidox Solutab with ureaplasma, the following are prescribed:

1. Probiotics are prescribed because antibiotics of any group negatively affect the microflora of the gastrointestinal tract, although the composition of the drug is such that irritation of the gastric mucosa does not occur, since doxycycline is present in it in the form of monohydrate with water, and that is why it is absorbed in the intestine.

After completing the course of admission and passing the examination, the patient is considered healthy. But many doctors recommend that the patient be given a second, preventive examination 2-3 months after the end of the course of treatment. This is due to the fact that genital ureaplasmosis is a recurrent disease.

Contraindications

A categorical contraindication for taking the drug is pregnancy and lactation, since the main active substance can penetrate the placental barrier and have Negative influence on the fetus, it also accumulates in breast milk, which is harmful to the child.

The drug is never prescribed to children under the age of 8 years. With dysfunction of the kidneys and liver, there may be contraindications for use. The period of complete elimination of the drug from the body is from 17 to 23 hours.

Content

Being an antibiotic of the tetracycline series, Unidox Solutab, an instruction for use in ureaplasma, which allows the use of the drug in the treatment of infection, even for children from 8 years old, is considered an effective medicine. An antibiotic is taken strictly with a doctor's prescription, but since the disease is opportunistic, its treatment is not always appropriate. In what cases can you take a drug whose main active ingredient is doxycycline - this is detailed in the article.

What is ureaplasmosis

The disease is considered one of the most common sexually transmitted diseases. In addition, it has been recorded that there is a risk of infection by airborne droplets and from mother to fetus. On the present stage the opinions of experts differ radically, since there is no definite view of the disease, since the causative agents of ureaplasmosis are present in more than half healthy women and one third of newborn girls. In men, it is extremely rare.

Pathogens are considered conditionally pathogenic, so the treatment of ureaplasma with an antibiotic, its expediency, is questionable, since there are several pathogenic types of ureaplasma that are not always relevant to treat:

• parvum. A bacterium that breaks down urea, releasing ammonia. At excessive concentration, it can cause the formation of stones in various parts of the urinary system. They are the most dangerous.
• urealiticum. It affects blood cells and sperm, and also has a detrimental effect on the mucous membrane.
• spices. Inhabits numerous cells of the mucosa, can cause the development of infertility in men.

Compound

As already noted, the active substance that is part of Unidox is doxycycline. As auxiliary substances, the composition of the drug includes:

• hypromellose;
• giprolose (low-substituted);
• colloidal (anhydrous) silicon dioxide;
• lactose monohydrate;
• magnesium stearate;
• saccharin;
• cellulose microcrystalline.

Is doxycycline effective for ureaplasma

The repeatedly proven effectiveness of Unidox in the treatment of ureaplasma allows the drug to be one of the main drugs in the treatment of the disease. To remove ureaplasma from the body, antibiotic treatment is considered the most progressive method. Particularly well proven drugs of the tetracycline group, so it can be argued that drug treatment gives its positive results.

How it works

The antibiotic, produced in the form of dispersible tablets engraved with "173", is active against the action of gram-negative and gram-positive microorganisms, since it is a broad-spectrum drug. However, the action of Unidox Solutab is selectively aimed at suppressing, among other things, ureaplasma by influencing the cellular structure of bacteria.

The drug not only inhibits the development of microorganisms, but also prevents their growth. Due to the fact that the absorption of the antibiotic occurs rapidly in the gastrointestinal tract, its penetration into many organs and tissues of the body, with the exception of the spinal cord, helps to increase the effectiveness of treatment at times. The indication for the use of Unidox Solutab exists even for people with diseased kidneys, since absorption occurs exclusively through the gastrointestinal tract.

The scheme of treatment of ureaplasma

In no case should you prescribe a drug for yourself, since only a specialist, after conducting various kinds of research, can talk about the possibility of prescribing Unidox from ureaplasma. Medical treatment consists not only in taking this antibiotic, but also in the inclusion of vaginal suppositories and douching in therapy. In addition, the doctor may prescribe Flucostat and Vilprafen - this scheme is considered more common and effective.

Unidox solutab - instructions for ureaplasma

According to the official instructions, the use of Unidox in ureaplasma is prescribed for a week, as for most antibiotics of the tetracycline group. You can order and buy the drug in the pharmacy network only by prescription, which is issued by the attending physician after the diagnosis. The shelf life of the antibiotic is 5 years, and it is required to store it in a dry place at a temperature not lower than 15 and not higher than 25 ° C.

While taking the drug, according to the instructions, alcohol is prohibited, since the concentration of Unidox Solutab in the blood decreases significantly. For this reason, treatment is considered ineffective. Women who are simultaneously treated with an antibiotic and taking contraceptives should be aware that the effectiveness of contraceptives is reduced when taken together. In addition, menstruation may go outside the schedule. Another feature is that it reduces the bioavailability of antacids, so it is necessary to make an interval between taking these drugs.

How to drink Unidox

Before taking Unidox with ureaplasma, you should carefully read the prescriptions and follow all the advice of your doctor. Instructions for use of the antibiotic does not indicate a special connection of the drug with the main meals, but only limits the time interval between taking the medicine - it must be constant. According to reviews, it is still recommended to use Unidox Solutab with meals or immediately after a meal, drinking tablets large quantity water.

Dosage

It is important to understand that the dosage of Unidox Solutab for ureaplasma depends entirely on the results of the previous study. The duration and doses of administration are prescribed purely individually, but, as a rule, the course of treatment lasts 7 days. If you turn to the instructions, then taking an antibiotic depends not only on the age of the patient, but also on his weight. If a person weighs more than 50 kg, on the first day it is necessary to take a double dose - 200 g, on the second and subsequent days, the treatment will be 100 g of the antibiotic once.

As can be seen from the title, and the word "solutab" is direct evidence of this, tablets can be chewed or dissolved in water and taken as a syrup. This is not forbidden by the instruction, especially when it comes to children, who sometimes find it difficult to swallow a whole pill at a time. For children, the dosage is calculated from their weight, with 4 mg of the drug for each kilogram on the first day, and 2 mg on the following days.

How many days to drink Unidox Solutab with ureaplasma

Only a few antibiotics have the effect of accumulation in the body, which makes it possible to take them for no more than 3 days. The minimum duration of taking Unidox is a week. In some particularly severe cases, it can be increased, but all this happens only as directed by the attending physician, if the results of treatment are disappointing.

Side effects

Like most drugs, side effects Unidox. The most common include vomiting and nausea, diarrhea, and abdominal pain. Some patients may experience inflammation of the pancreas and colon. Erosion of the esophagus is not excluded, therefore it is recommended to take the antibiotic strictly in a standing position. When taking tests, there may be a violation of the microflora of the vagina and intestines and fungal infections can be noted.

Unidox price

It is noteworthy that the antibiotic, compared to other similar drugs - and there are a considerable number of them - has an acceptable cost, which makes it indispensable in treatment from a financial point of view. When selling the drug in online pharmacies in Moscow and St. Petersburg, an additional fee may be charged for the delivery of the order to the specified address. Further in the table, you can see approximately how much tablets cost in a package of 10 pieces in the capital region.

The drug Unidox Solutab contains the active substance - doxycycline - an antibiotic of the tetracycline group. Doxycycline has a bacteriostatic effect due to the inhibition of the synthesis and metabolism of proteins contained in the cell membrane of microorganisms.

In addition, the drug disrupts the connection of certain types of RNA with the ribosome membrane. Unidox Solutab is characterized by a significantly higher activity against cultures of microorganisms that are in the functional stage of growth and division, at the same time, the drug has practically no effect on microorganisms at the dormant stage.

In this article, we will consider why doctors prescribe Unidox Solutab, including instructions for use, analogues and prices for this drug in pharmacies. If you have already used Unidox Solutab, leave your feedback in the comments.

Composition and form of release

Clinical and pharmacological group: antibiotic of the tetracycline group.

The active substance Unidox Solutaba doxycycline monohydrate is supplemented with microcrystalline cellulose, lactose monohydrate, saccharin, colloidal silicon dioxide anhydrous low-substituted hyprolose, magnesium stearate and hypromellose in the required amount.

The drug is produced in the form of tablets that dissolve in oral cavity and do not need to be swallowed. The shape is biconvex, round. Light yellow color with a hint of grey. On one side there is a dividing risk and code inscription 173 on the other side.

What is Unidox Solutab used for?

Indications for the use of Unidox Solutab are the following diseases caused by bacteria:

Diseases genitourinary system:

• cystitis;
• endometritis;
• urethritis;
• gonorrhea;
• prostatitis caused by a bacterium;
• pyelonephritis;
• syphilis;
• chlamydial infections;
• urogenital mycoplasmosis.

Diseases digestive system and biliary tract:

• dysentery;
• cholecystitis;
• gastroenterocolitis;
• traveler's diarrhea;
• cholera;
• yersiniosis;
• cholangitis.

Diseases respiratory system and ENT organs:

• acute bronchitis;
• tracheitis;
• pneumonia;
• pharyngitis;
• tonsillitis;
• otitis;
• sinusitis;
• lung abscess.

Other diseases:

• eye infections;
• sepsis;
• osteomyelitis;
• infections from insect or animal bites;
• chlamydia;
• whooping cough;
• proctitis;
• Lyme disease;
• plague;
• malaria;
• ornithosis;
• bartonellosis;
• psittacosis;
• brucellosis;
• skin and soft tissue infections;
• peritonitis.

pharmachologic effect

The drug contains the active substance - doxycycline - an antibiotic of the tetracycline group. Doxycycline has a bacteriostatic effect due to the inhibition of the synthesis and metabolism of proteins contained in the cell membrane of microorganisms.

In addition, the drug disrupts the connection of certain types of RNA with the ribosome membrane. The drug is characterized by a significantly higher activity against cultures of microorganisms that are in the functional stage of growth and division, at the same time, the drug has practically no effect on microorganisms in the dormant stage.

Instructions for use

The duration of administration and dosage of the drug should be prescribed by a doctor, depending on the disease and its course. Tablets are swallowed whole or crushed into powder and mixed with water. The drug is preferably taken with meals. Take pills while sitting or standing, which reduces the likelihood of developing esophagitis and esophageal ulcers. The drug should not be taken immediately before bedtime.

• Adults and children over 8 years of age weighing more than 50 kg on the first day of treatment are prescribed 200 mg / day in 1 or 2 doses, on subsequent days of treatment - 100 mg / day in 1 dose. In case of severe infections, 200 mg / day is prescribed for the entire period of treatment.
• For children aged 8-12 years weighing less than 50 kg, the average daily dose is 4 mg / kg on the first day, then 2 mg / kg / day (in 1-2 doses). In cases of severe infections, the drug is prescribed at a dose of 4 mg / kg daily during the entire treatment.

Average dosage depending on the disease:

• For uncomplicated gonorrhea(with the exception of anorectal infections in men), adults are prescribed 100 mg 2 times / day until complete cure (on average within 7 days), or 600 mg is prescribed for one day - 300 mg in 2 doses (second dose after 1 hour after the first).
• For uncomplicated urogenital infections caused by Chlamydia trachomatis, cervicitis, non-gonococcal urethritis caused by Ureaplasma urealiticum, 100 mg is prescribed 2 times / day for 7 days.
• For primary syphilis appoint 100 mg 2 times / day for 14 days, with secondary syphilis - 100 mg 2 times / day for 28 days.
• To prevent traveler's diarrhea- 200 mg on the first day of the trip in 1 or 2 doses, then - 100 mg 1 time / day during the entire stay in the region (no more than 3 weeks).
• To prevent malaria appoint 100 mg 1 time / day for 1-2 days before the trip, then daily during the trip and within 4 weeks after returning; children over 8 years old - 2 mg / kg 1 time / day. The duration of prophylaxis should not exceed 4 months.
• For acne appoint 100 mg / day, the course of treatment is 6-12 weeks.
• To prevent infections during medical abortion prescribe 100 mg 1 hour before and 200 mg after the intervention.
• For the treatment of leptospirosis- 100 mg orally 2 times / day for 7 days; for the prevention of leptospirosis - 200 mg 1 time / week during your stay in a disadvantaged area and 200 mg - at the end of the trip.
• For infection caused by Streptococcus pyogenes, the duration of treatment is at least 10 days.

Maximum daily doses for adults - up to 300 mg / day or up to 600 mg / day for 5 days in severe gonococcal infections. For children over 8 years old weighing more than 50 kg - up to 200 mg, for children 8-12 years old weighing less than 50 kg - 4 mg / kg daily during the entire treatment.

Contraindications

The drug Unidox Solutab should not be used in such cases:

• severe pathological changes in the liver and kidneys;
• pregnancy and lactation period;
• allergic reactions to the use of tetracyclines;
• children under 12;
• porphyria.

Side effects

When using the drug, the following adverse reactions may develop:

1. Manifestations of allergic reactions: urticaria, anaphylactic reactions, exacerbation of systemic lupus erythematosus, angioedema, pericarditis, erythema multiforme.
2. Manifestations from the nervous system when using Unidox solutab: increased intracranial pressure ( headache, vomiting, swelling of the optic nerve), vestibular changes (dizziness), blurred vision, double vision.
3. Skin manifestations: exfoliative dermatitis, photosensitivity, maculo-papular and erythematous rash.
4. Manifestations from the circulatory system: hemolytic anemia, decrease in prothrombin activity, thrombocytopenia, neutropenia, eosinophilia.
5. Manifestations from the endocrine system: in patients who have received doxycycline for a long time, reversible staining of the thyroid tissue in a dark brown color may occur.
6. Gastrointestinal manifestations: nausea, vomiting, diarrhea, dysphagia, anorexia, enterocolitis, esophageal ulcer, pseudomembranous colitis, esophagitis, darkening of the tongue, liver damage (with prolonged use or in patients with renal and hepatic insufficiency), cholestasis.
7. Manifestations from the urinary system: increased residual urea nitrogen (as a result of antianabolic action).
8. Manifestations from the musculoskeletal system: doxycycline disrupts the normal formation of teeth in children, irreversibly changing the shade of the teeth (enamel hypoplasia appears).

Other manifestations when using Unidox Solutab: causes candidiasis (stomatitis, proctitis, vaginitis) as a superinfection.

Pregnancy and lactation

Unidox Solutab is not used during pregnancy, unless the drug is the only remedy for the treatment or prevention of especially dangerous and severe infections (rocky mountain spotted fever, inhalation exposure to Bacillus anthracis and others).

The active substance Unidox Solutab is Doxycycline, it passes into breast milk. Due to adverse effects on the fetus, doxycycline, like other tetracyclines, is not used during breastfeeding. If the appointment of tetracyclines is necessary, breastfeeding should be discontinued.

Doxycycline or Unidox Solutab - which is better?

The main difference between the drugs is the fact that Unidox does not affect the stomach so much and does not cause side effects characteristic of doxycycline (stomach ulcer, gastritis).

Absorption of the active substance occurs in the intestine and almost 100% of the drug is absorbed by the body. The only advantage of doxycycline is its extremely low cost compared to the original.

Analogues

The most common analogues: vibramycin d, doxibene, doxycycline hydrochloride, tetracycline hydrochloride, dox-m-ratiopharm, doxycycline, tigacil. The price of analogs differs significantly from the original, most often it is lower.

Prices

The average price of UNIDOX SOLUTAB in pharmacies (Moscow) is 310 rubles.

Storage conditions

At temperatures from 15 to 25 ºС. Keep out of the reach of children! Shelf life: 5 years. Do not use after the expiry date stated on the package.

Unidox Solutab instruction

Instructions for use Unidox Solutab contains Full description drug and its action: composition, indications, use in treatment, contraindications, side effects, cost, analogues and reviews.

Form, composition, packaging

The drug is released in the form of tablets that dissolve in the oral cavity and do not need to be swallowed. The shape is biconvex, round. Light yellow color with a hint of grey. On one side there is a dividing risk and code inscription 173 on the other side.

The active substance Unidox Solutaba doxycycline monohydrate is supplemented with microcrystalline cellulose, lactose monohydrate, saccharin, colloidal silicon dioxide anhydrous low-substituted hyprolose, magnesium stearate and hypromellose in the required amount.

The packaging of the drug is a pack of cardboard, which contains a blister with ten tablets.

Terms and conditions of storage

The drug is stored in temperature conditions from 15 to 25 degrees for no more than five years. Children to storage medicinal product should not be allowed.

Pharmacology

Unidox Solutab belongs to the antibiotics of the tetracycline group with a wide spectrum of action. It is capable of bacteriostatic effects and inhibition of the process of synthesizing cellular protein in a pathogen cell, which is due to its interaction with ribosome subunits (30S).

The activity of the drug extends to a number of gram-negative and gram-positive anaerobes, including some protozoa.

However, if resistance occurs, which is acquired by some pathogens to the active component of the drug, the resistance of the pathogen to any drug from this group should be taken into account.

Pharmacokinetics

Absorption of the drug, which is not affected by food intake, is fast and occurs almost completely. The maximum concentration in the blood plasma of doxycycline reaches two hours after taking the pill.

With plasma proteins, the active substance of the drug binds to 90 percent, which is reversible and has a good ability to penetrate into tissues. The level of penetration into the cerebrospinal fluid is low and amounts to no more than 20 percent of the total concentration in the blood plasma. When liver function maintains normal levels, the drug is ten times more concentrated in bile than in plasma. Up to 25 percent of the total concentration of doxycycline, the active substance is found in the salivary fluid.

There is a penetration of doxycycline through the placental barrier and a small amount into maternal milk.

Dentin and bone tissue can accumulate the active substance Unidox Solutaba.

The metabolic process affects only a small part of doxycycline.

The half-life after the drug is taken orally once lasts up to eighteen hours, repeated doses are excreted for more than a day.

Slightly less than half of the dose can be excreted by the kidneys through the biologically active form, the rest goes through the intestines in the form of inactive chelates.

Unidox Solutab indications for use

The drug Unidox Solutab is prescribed for treatment to those patients who suffer from infectious and inflammatory diseases that are caused by those microorganisms that are sensitive to the effects of the drug.

Infectious diseases of the respiratory tract

• treatment of pharyngitis;
• pleural empyema;
• acute bronchitis;
• lung abscess;
• obstructive pulmonary disease in the acute stage;
• tracheitis;
• community-acquired pneumonia;
• lobar pneumonia;
• bronchopneumonia.

Infectious diseases of the ENT organs

• treatment of otitis;
• tonsillitis;
• sinusitis.

Diseases of the genitourinary system of an infectious nature

• treatment of cystitis;
• endometritis, salpingoophoritis and endocercevit in combination with other medicines;
• pyelonephritis;
• bacterial prostatitis;
• orchiepididymitis in acute form;
• urethritis;
• mycoplasmosis urogenital;
• urethrocystitis.

Infectious diseases that are sexually transmitted

• treatment of chlamydia urogenital;
• venereal lymphogranuloma;
• syphilis in those patients who do not tolerate penicillin;
• inguinal granulomas;
• gonorrhea uncomplicated.

Infectious diseases of the biliary tract and digestive tract

• treatment of traveler's diarrhea;
• cholera;
• amoebic or bacillary dysentery;
• yersiniosis;
• gastroenterocolitis;
• cholangitis;
• cholecystitis.

Skin infections

• treatment of wound infections as a consequence of an animal bite;
• severe acne as a component of combined therapy.

Eye infections

• treatment of trachoma in combination with other medicines.

Other infectious and inflammatory diseases

• yaws treatment;
• brucellosis;
• legionellosis;
• whooping cough;
• chlamydia;
• erchiliosis granulocytic;
• rickettsiosis;
• bartonellosis;
• Q fever;
• spotted fever of the Rocky Mountains;
• bartonellosis;
• typhus;
• Lyme disease;
• anthrax;
• tularemia;
• ornithosis;
• plague;
• psittacosis;
• actinomycosis;
• leptospirosis;
• malaria;
• osteomyelitis;
• peritonitis;
• septic subacute endocarditis;
• sepsis.

Contraindications

There are also contraindications to the appointment, therefore, when considering the option of treating a particular disease with the participation of this drug, attention should be paid to them. Unidox Solutab should not be administered:

• in case of violations of the functionality of the kidneys or liver in a severe form in the patient;
• with a high level of hypersensitivity to antibiotics of this group;
• porphyria;
• pregnancy and feeding;
• children under eight years of age.

Unidox Solutab instructions for use

You can take the drug different ways: dissolve in a small amount of water to obtain a suspension, swallow, divide into parts or chew, accompanying with drinking. It is advisable to take the medicine, combining with food at least two hours before bedtime.

The duration of therapy is not more than ten days.

For adult patients and children after reaching eight years of age, the body weight of which exceeds fifty kilograms, is prescribed on the first day of treatment at 200 milligrams per day in one or two doses, then 100 milligrams per day once. When the infection is severe, 200 milligrams per day can be used daily.

When the body weight of a child older than eight years does not reach 50 kilograms, the drug is prescribed at an average daily dose of 4 milligrams per kilogram of weight on the first day of treatment and then 2 milligrams per kilogram of body weight per day. In severe infections, you can use the dosage of the first day daily.

streptococcal infection

Treatment lasts up to ten days.

Gonorrhea uncomplicated

Adults: 100 milligrams twice a day for a week or for one day of treatment, 300 milligrams twice a day. The second dose should be taken one hour after the first.

Syphilis primary

100 milligrams twice a day for two weeks.

Syphilis secondary

100 milligrams twice a day for four weeks.

Uncomplicated urogenital infections

100 milligrams 2 times a day for a week of admission.

Acne

100 milligrams for one day. The duration of admission is from 6 to 12 weeks.

Leptospirosis (treatment)

100 milligrams 2 times a day for a week.

Prevention

• malaria: 100 mg. per day a day or two before the start of the trip, directly during the trip every day and within a month after its completion. Children after 8 years: 2 mg/kg of body weight per day. Taking the drug prophylactically should not exceed four months.
• travelers diarrhea: 200 mg. on the first day of travel and then 100 mg. all other days. Reception to carry out no more than three weeks.
• leptospirosis: 200 mg. once a week for the entire period of stay in an area with an unfavorable situation regarding this infection and then at the end of the stay another 200 mg.
• infection during medical abortion: 100 mg. an hour before the procedure and 200 mg. upon its completion.

The maximum allowable daily dose of the drug

For an adult patient: 300 milligrams;

For a child after 8 years (body weight over 50 kg.): 200 milligrams;

For a child after 8-12 years (body weight less than 50 kg.): 4 mg / kg.

For patients suffering from renal insufficiency, it is necessary to reduce the dose of the drug.

Unidox Solutab during pregnancy

During pregnancy, Unidox Solutab is contraindicated. However, with an urgent need to treat a woman, his appointment takes place. It should be taken into account that doxycycline as the active substance of the drug can have a very adverse effect on the development of the fetus. Therefore, by the time of the appointment of treatment, pregnancy is desirable to exclude. Breast-feeding prohibited due to the penetration of doxycycline into a woman's milk.

Unidox Solutab for children

Side effects

Effects that qualify as side effects from taking Unidox Solutab affect various systems organism.

Digestive system

Patients complain of the development of dysphagia, vomiting and nausea, diarrhea, anorexia, pseudomembranous colitis, enterocolitis, esophageal ulcer, esophagitis, cholestasis, and staining of the tongue dark color. When long-term treatment takes place, it is possible that the liver will be affected. This is especially true for patients with hepatic or renal insufficiency.

Dermatology

In the form of photosensitivity, as well as the development of exfoliative dermatitis and erythematous or maculo-papular rash.

Allergy

Possible reactions in the form of urticaria, erythema multiforme, angioedema, anaphylactic reactions, pericarditis, a syndrome similar to serum sickness and systemic lupus erythematosus in the form of an exacerbation.

hematopoiesis

Perhaps the development of hemolytic anemia, eosinophilia, neutropenia, thrombocytopenia and a decrease in prothrombin activity.

endocrine system

In those patients who have taken the drug for a long time, the tissue of the thyroid gland may stain with a dark brown color. This phenomenon is reversible.

nervous system

There were complaints of double vision and visual blurring. Dizziness also occurred, and vestibular disorders increased HF pressure.

Urinary system

In the form of increases in residual nitrogen in urea.

Muscle and bone system

Osteogenesis slows down, normal dental development in children is disturbed in the form of enamel hypoplasia and changes in their color.

Other

In the form of manifestations of superinfection: candidiasis, vaginitis, glossitis, proctitis, stomatitis.

Overdose

Symptoms of drug overdose are those side effects, which will increase with a detrimental effect on the liver. They will manifest themselves in the form of fever, vomiting, azotemia, jaundice, increased levels of transaminases and prothrombin time.

The patient should be treated with immediate gastric lavage and initiation of vomiting after heavy drinking. Activated charcoal and osmotic laxatives are prescribed. Conducting hemodialysis and peritoneal dialysis is not effective.

Drug Interactions

While taking doxycycline with various medications, the following effects may be observed:

• combination with antacids containing magnesium, calcium, aluminum, as well as iron preparations, sodium bicarbonate and magnesium-containing laxatives can reduce the absorption of doxycycline. Therefore, they are taken with a break of at least three hours.
• The dosage of indirect anticoagulants will require adjustment, since doxycycline suppresses the intestinal microflora, which in turn leads to a decrease in the prothrombin index.
• The effectiveness of bactericidal antibiotics is reduced.
• The reliability of contraceptives that contain estrogen hormones is markedly reduced and the risk of acyclic bleeding increases.
• The concentration in the blood plasma of doxycycline will be reduced when combined with ethanol, barbiturates, carbamazepine, phenytoin, rifampicin.
• Retinol together with doxycycline affects the increase in intracranial pressure.

Additional instructions

In connection with the possibility of influencing the prothrombin time, the administration of the drug to those patients who suffer from coagulopathy should be carefully monitored.

It should be monitored taking the drug in patients with impaired renal function in order to avoid an increase in azotemia.

Long-term treatment with the drug leads to the need to control blood laboratory parameters and the functionality of the kidney and liver.

To avoid negative consequences, it is necessary to warn the patient about limiting exposure to the sun in the initial period of treatment.

With the development of diarrhea during treatment drug Unidox Solutab should cancel the medication followed by the appointment of ion-exchange resins. In especially difficult situations, it is necessary to compensate for the loss of fluid, proteins and electrolytes by the body and prescribe the drugs vancomycin and metronidazole.

You should not combine treatment with taking drugs that have an effect of inhibition on intestinal motility.

Long-term treatment is fraught with dysbacteriosis.

To reduce the likelihood of occurrence of dyspeptic phenomena, it is necessary to take the medication during meals.

With the development of side effects in the form of dizziness, double vision and blurred vision, the patient should not drive a vehicle or carry out other activities related to technical means.

Unidox Solutab analogues

Xedocin tablets are considered an analogue of the drug Unidox Solutab.

Unidox Solutab price

The cost of the drug on average in pharmacies is approximately from 300 to 330 rubles.

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